Carbamazepine is used commonly to control seizures and epilepsy in children and adults. Due to known adverse effects like red blood cell destruction and aplastic anaemia, monitoring levels is necessary in chronic use.
This heterocyclic (iminostilbene) compound has potent antiepileptic properties and is effective alone or with other antiepileptic drugs in partial seizures, especially complex partial seizures, generalized tonic-clonic seizures, and combinations of these seizure types.
Carbamazepine generally is ineffective for absence, myoclonic, and atonic seizures. In children with symptomatic generalized epilepsy and continuous spike-and-wave discharge, these seizure types may develop or tonic-clonic seizures may increase in frequency with use of carbamazepine.
This drug is increasingly preferred to phenobarbital in pediatric patients because it has less effect on cognition and behavior. It is reported to have psychotropic activity that may increase alertness and elevate mood in depressed epileptic patients, but not in otherwise normal patients. Mental improvements may be due to substitution of carbamazepine for sedative drugs, control of seizures, or a direct psychotropic effect.
Monitoring therapy with carbamazepine
No special preparation is necessary prior to blood sample collection.
Carbamazepine (Tegretol) Serum – TC – 26513
Estimated Turn Around For Results:
2-10 Business Days
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