C1, C1q, C2, C3, C4, CH50, CH100, Complement, or Total Complement
The Purpose of a CH50 Test
Your immune system relies on proteins in the complement system to do its job in keeping you strong and healthy by protecting your body from germs. The nine major proteins are numbered (C1-C9) and can be measured independently, but the CH50 measures them all at once. This helps diagnose or monitor autoimmune disorders or infections.
Quest
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Complement, Total (CH50) (618)
Labcorp
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Complement, Total (CH50) (001941)
What Does the CH50 Measure?
This test will determine if you have enough of the major complement proteins in your body to support a healthy immune system.
Who Should Take a CH50 Lab Test?
Your physician may recommend a CH50 test if you have (or are suspected of having) an autoimmune disorder such as lupus or rheumatoid arthritis. This test is also beneficial if you are being treated for a disease associated with a weakened immune system, or if you have persistent or chronic infections or inflammation.
CH50 Complement Preparation
There are no special preparations or instructions for taking a CH50 blood test.
CH50 Test Results
Results in the CH50 normal range indicate that your complement protein levels are adequate for your needs.
Low CH50 levels may suggest you have lupus, rheumatoid arthritis, nutritional deficiency, infection, kidney disease, or other issues that may require further testing. For instance, you could individually test your C3 or C4 protein levels to rule out the possibility of lupus.
If you have CH50 high levels, you may need further testing for cancer (such as leukemia) or ulcerative colitis.
A CH50 lab test gives you valuable information you can use to get the proper treatment, which could include lifestyle modifications or medication.
Where Can I Get a Complement Total CH50 Test Near Me?
Take your CH50 complement blood test at one of our partner Labcorp or Quest Diagnostic labs across the country. With more than 4,000 locations, you get blood testing with ease and convenience.
Here’s how the process works:
Step 1: Buy your test online and download the lab order. (You don’t need a physician’s approval to order a test, depending on the state you live in.)
Step 2: Visit our lab locator to find the facility nearest you and schedule the blood work.
Step 3: Bring the lab order with you to your appointment.
Step 4: Results are sent to your secure Personalabs portal, usually within 2 to 10 business days. (If you need a specific turnaround time, contact us and we will reach out to the lab on your behalf, as times can vary.)
Get the data you need to take control of your healthcare decisions. Order your Personalabs test today.
Additional information
Provider
LabCorp, Quest
STEP 1
Order Your Test
Create an account, choose your tests, checkout securely, generate your lab order
STEP 2
Generate & Print Out Lab Order
Our physician network will approve your order within 2-4hrs.
Results can be provided in as little as 24-48 hrs. For more complex tests, please contact us for turn around times.
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The CH50 blood test is recommended for individuals suspected of having autoimmune disorders, such as lupus or rheumatoid arthritis, as it helps assess complement system function and diagnose related conditions.
What is the normal range for CH50 blood test results?
The normal range for CH50 blood test results typically falls between 60 to 180 units per milliliter (U/mL). However, reference ranges may vary slightly depending on the laboratory conducting the test.
What is the role of the CH50 test in diagnosing membranoproliferative glomerulonephritis?
The role of the CH50 test in diagnosing membranoproliferative glomerulonephritis is to assess the complement system's function, helping to identify abnormalities that may indicate immune-mediated damage associated with this condition.
Is a high CH50 level a sign of inflammation?
A high CH50 level may indicate inflammation in the body. This test measures the total complement activity, and elevated levels can suggest an ongoing immune response or autoimmune disorder.
What does a high CH50 blood test result indicate?
A high CH50 blood test result indicates increased complement activity, which may suggest the presence of autoimmune disorders, infections, or inflammatory conditions. Further evaluation by a healthcare professional is recommended to determine the underlying cause.
What causes high CH50 levels in the blood?
High CH50 levels in the blood are typically caused by conditions that stimulate the immune system, such as infections, autoimmune diseases, or inflammatory disorders.
What is the primary purpose of the CH50 test in laboratory diagnosis?
The primary purpose of the CH50 test in laboratory diagnosis is to assess the overall function of the complement system, which plays a crucial role in the immune response and can help identify autoimmune disorders or complement deficiencies.
Can the CH50 test be used to screen for complement deficiencies?
The CH50 test can be utilized to screen for complement deficiencies. By measuring the total complement activity, it helps identify potential issues within the complement system, which may indicate deficiencies related to autoimmune disorders or other medical conditions.
What is the purpose of a CH50 blood test?
The purpose of a CH50 blood test is to measure the total complement activity in the blood, which helps diagnose and monitor autoimmune disorders and conditions related to the immune system.
How does the CH50 test help diagnose autoimmune disorders?
The CH50 test helps diagnose autoimmune disorders by measuring the total complement activity in the blood, which can indicate abnormalities in the immune system, often associated with conditions like lupus or rheumatoid arthritis.
What conditions does the CH50 test evaluate?
The CH50 test evaluates complement system activity, which can help diagnose conditions such as autoimmune disorders, infections, and certain types of kidney disease.
Can the CH50 test detect complement system issues?
The CH50 test can detect complement system issues by measuring the total complement activity in the blood. Low levels may indicate problems related to autoimmune disorders or other conditions affecting the complement system.
What is the significance of low CH50 levels?
The significance of low CH50 levels indicates a potential deficiency in the complement system, which may suggest underlying autoimmune disorders or increased susceptibility to infections. It is essential to consult a healthcare provider for further evaluation.
How is CH50 testing performed in the lab?
The CH50 testing is performed in the lab by obtaining a blood sample from the patient, which is then analyzed to measure the total complement activity in the serum, helping to assess immune system function.
What factors can affect CH50 test results?
Factors that can affect CH50 test results include recent infections, autoimmune diseases, medications, and the presence of other underlying health conditions. These elements can influence complement levels and lead to variations in test outcomes.
Are there any preparations needed for CH50 testing?
Preparations needed for CH50 testing are minimal. Generally, fasting is not required, but it's advisable to consult your healthcare provider for any specific instructions related to your individual health circumstances.
How often should CH50 levels be monitored?
The frequency of monitoring CH50 levels depends on individual health conditions and physician recommendations. Typically, it may be assessed periodically to track autoimmune disorders or treatment responses, often every few months or as advised by your healthcare provider.
What symptoms might prompt a CH50 test?
Symptoms that might prompt a CH50 test include unexplained fatigue, joint pain, skin rashes, and frequent infections, as these can indicate underlying autoimmune disorders or complement system abnormalities.
Can medications interfere with CH50 test outcomes?
Medications can interfere with CH50 test outcomes. It's important to inform your healthcare provider about any medications you are taking, as some may affect the results of the test.
Who interprets CH50 test results in laboratories?
The interpretation of CH50 test results in laboratories is typically conducted by qualified medical professionals, such as pathologists or laboratory technicians, who analyze the data and provide insights regarding complement system function and potential autoimmune disorders.
What additional tests may accompany CH50 assessment?
Additional tests that may accompany the CH50 assessment include individual complement component tests, such as C3 and C4, as well as autoimmune panels, which help provide a comprehensive evaluation of immune system function and potential disorders.
How are CH50 results communicated to patients?
The communication of CH50 results to patients is typically done through secure online portals, where patients can view their results directly. Additionally, healthcare providers may discuss the results during follow-up appointments.
What follow-up steps occur after abnormal CH50 results?
The follow-up steps after abnormal CH50 results include consulting with a healthcare provider to discuss the findings, potential additional testing to identify the underlying cause, and developing an appropriate treatment plan based on the diagnosis.
Is fasting required before a CH50 blood test?
Fasting is not required before a CH50 blood test. You can eat and drink normally prior to the test, which makes it convenient to schedule your appointment.
Can children undergo CH50 testing effectively?
Children can effectively undergo CH50 testing, as the test is suitable for all ages. It helps assess complement system function, aiding in the diagnosis of autoimmune disorders in pediatric patients.
How reliable is the CH50 blood test?
The reliability of the CH50 blood test is generally high, as it effectively measures complement activity and can help diagnose autoimmune disorders. However, results should always be interpreted in conjunction with clinical findings and other diagnostic tests.
What trends are seen in increasing CH50 levels?
Trends in increasing CH50 levels indicate heightened immune system activity, often associated with infections, inflammatory conditions, or autoimmune disorders. Monitoring these levels can help in understanding underlying health issues.
What lab errors can affect CH50 testing accuracy?
Lab errors that can affect CH50 testing accuracy include improper sample handling, contamination, incorrect storage temperatures, and delays in processing. These factors can lead to inaccurate results and misinterpretation of complement system function.
How long does it take to receive CH50 results?
The time it takes to receive CH50 results typically ranges from 1 to 3 business days after the test is completed.
Where can I order a CH50 blood test online?
You can order a CH50 blood test online through Personalabs. Simply visit their website, select the test, and follow the instructions to complete your order.
Needed to reschedule the lab date, and after messaging them 2 tim
Review of 8/2/2025, reflecting an experience on 7/16/2025 by W W