📅 Last Updated: May 2026 | 🩺 Medically Reviewed by: Edward Salko, D.O., Medical Director | 🧪 Lab Partner: Labcorp
Amenorrhea — the absence of menstrual periods — has multiple causes that require different treatments. A missed period from PCOS requires a completely different approach than a missed period from hypothalamic suppression, thyroid disease, elevated prolactin, or premature ovarian insufficiency.
The Amenorrhea Profile measures the key hormonal markers that identify which system is causing the problem — so you can get the right answer instead of guessing.
Order online, visit any Labcorp location nationwide, results in your private portal in days. No doctor visit required. HSA and FSA eligible.
Also Known As
Amenorrhea Panel Blood Test
Purpose of the Amenorrhea Blood Test
You have amenorrhea if you are unable to menstruate, typically for at least three consecutive cycles. Sometimes this is a natural result of pregnancy or menopause. But other times, amenorrhea is a signal of another health issue, such as polycystic ovarian syndrome, which can, in turn, affect your fertility. Amenorrhea labs can help you determine what the problem is so you can take care of your reproductive health.
What Does the Amenorrhea Profile Test Measure?
The amenorrhea test measures the serum level of three hormones: luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin. LH and FSH are produced by the pituitary gland and are essential in the regulation of the menstrual cycle and stimulation of egg production in the ovaries. Prolactin is manufactured by the pituitary as well as other parts of the body, including the mammary glands and uterus, to promote breast milk production and lactation.
Who Should Take an Amenorrhea Test?
Women may need an amenorrhea profile test if their period has stopped and hasn’t returned. Other related symptoms may include headaches, hair loss, or impaired vision. Testing may also be advised for women with a family history of this condition.
Amenorrhea Labs Preparation
You typically don’t need to take any special precautions prior to giving your blood sample. Talk with the lab if you are on medication to ensure it won’t influence your test results.
Amenorrhea Blood Test Results
The normal test results for each marker in the amenorrhea panel blood test include:
- LH: 5 to 25 IU/L (premenopausal women); 14.2 to 52.3 IU/L (postmenopausal women)
- FSH: 4.7 to 21.5 mIU/mL (menstruating women); 25.8 to 134.8 mIU/mL (postmenopausal women)
- Prolactin: Less than 25 ng/mL (women who aren’t pregnant); 80 to 400 ng/mL (pregnant women)
Amenorrhea Profile — Markers and What Each One Reveals
| Marker | What It Measures | What Abnormal Results Suggest |
|—|—|—|
| FSH | Pituitary signal to ovaries | High FSH = premature ovarian insufficiency. Low FSH = hypothalamic amenorrhea |
| LH | Pituitary ovulation trigger | High LH with high LH/FSH ratio = PCOS. Low LH with low FSH = hypothalamic suppression |
| Estradiol | Primary estrogen production | Low estradiol with high FSH = ovarian failure. Low estradiol with low FSH = hypothalamic cause |
| Prolactin | Pituitary hormone — inhibits ovulation when elevated | Elevated prolactin = hyperprolactinemia — most common reversible cause of amenorrhea |
| TSH | Thyroid function | Both hypothyroidism and hyperthyroidism cause amenorrhea |
| Total Testosterone | Androgen levels | Elevated testosterone with LH/FSH >2:1 = PCOS pattern |
The 5 Most Common Causes of Amenorrhea — and How This Panel Identifies Each One
Missing periods are always a signal that something has changed in the hormonal system. The Amenorrhea Profile identifies the five most common hormonal causes with a single blood draw.
PCOS (Polycystic Ovary Syndrome) — the most common cause of amenorrhea in women of reproductive age. Pattern: elevated LH, normal or low FSH, LH/FSH ratio above 2:1, elevated testosterone, low or normal estradiol. PCOS causes anovulation — no ovulation, no progesterone surge, no period.
Hypothalamic amenorrhea — caused by excessive exercise, very low body weight, caloric restriction, or high psychological stress. The hypothalamus suppresses GnRH, shutting down the entire reproductive axis. Pattern: low FSH, low LH, low estradiol. All three suppressed together points toward central suppression rather than an ovarian or pituitary problem.
Hyperprolactinemia — elevated prolactin from a pituitary adenoma, medication side effect, or hypothyroidism directly inhibits
GnRH release and stops ovulation. Pattern: elevated prolactin — often with low FSH and low LH. Most pituitary adenomas causing amenorrhea are small, benign, and treatable.
Premature ovarian insufficiency (POI) — ovarian failure before age 40. Pattern: very high FSH (above 25 IU/L), very high LH,
very low estradiol. The pattern is identical to menopause but occurs in a much younger woman. POI affects 1% of women under 40 and is frequently misdiagnosed or delayed.
Thyroid dysfunction — both hypothyroidism and hyperthyroidism disrupt the menstrual cycle. Hypothyroidism causes heavy, irregular, or absent periods through multiple mechanisms including elevated prolactin. Pattern: abnormal TSH with the reproductive hormones otherwise not fitting another clear pattern.
One blood draw identifies which of these five systems is the cause — or rules them all out, pointing toward a structural or
anatomical evaluation.
Reviewed by Edward Salko, D.O., Medical Director, Personalabs
Where Can I Get a Test for Amenorrhea Near Me?
Personalabs makes hormone testing for women accessible and convenient, so you can get the answers you need and deserve when it comes to your health. How easy is it? Just follow these easy steps:
- Visit our hormone testing section, buy the test for amenorrhea, and download the accompanying lab order. (You may not need a doctor’s approval to get your test, depending on the state where you live.)
- Select the lab closest to you and schedule your blood draw. You can choose from more than 2,000 Labcorp partner labs across the country.
- Take your test order to the lab and give your blood sample.
- Find your results in your secure and confidential Personalabs account, typically within 2 to 5 business days.
Explore our diverse selection of men’s and women’s health tests. You’ll find the ones you need to make informed healthcare decisions and take positive, proactive steps toward maintaining a vibrant state of well-being. Shop our tests online today.
Frequently Asked Questions: Amenorrhea Profile Blood Test
What does the Amenorrhea Profile blood test include?
The Amenorrhea Profile includes FSH, LH, Estradiol, Prolactin, TSH, and Total Testosterone. Together these six markers identify the most common hormonal causes of absent or irregular periods — including PCOS, hypothalamic amenorrhea, hyperprolactinemia, premature ovarian insufficiency, and thyroid dysfunction.
What is the most common cause of amenorrhea?
PCOS is the most common cause of amenorrhea in women of reproductive age — affecting 1 in 10 women. The classic hormonal pattern is elevated LH with a LH/FSH ratio above 2:1, elevated testosterone, and low or normal estradiol. Hyperprolactinemia — elevated prolactin from a pituitary adenoma or medication — is the most common reversible single-hormone cause.
What is hypothalamic amenorrhea?
Hypothalamic amenorrhea occurs when the hypothalamus suppresses GnRH release due to excessive exercise, very low body weight, severe caloric restriction, or high psychological stress. The hormonal pattern is low FSH, low LH, and low estradiol — all three suppressed together. It is the most common cause of amenorrhea in female athletes and women with eating disorders.
What is premature ovarian insufficiency?
Premature ovarian insufficiency (POI) is ovarian failure before age 40 — affecting 1% of women under 40. The hormonal pattern mirrors menopause — very high FSH above 25 IU/L, elevated LH, and very low estradiol. POI is frequently misdiagnosed as stress or PCOS and requires prompt identification because of its significant implications for fertility and bone health.
Can I order an amenorrhea blood test without a doctor?
Yes. Personalabs provides the physician-approved lab order with your purchase. Order online, visit any Labcorp patient service center near you, and get results in your private secure account within 24 to 48 hours. No fasting required. HSA and FSA eligible.
