Comprehensive Male Sexual Health and Wellness Blood Test

📅 Last Updated: April 2026  |  🩺 Medically Reviewed by: Edward Salko, D.O., Medical Director  |  🧪 Lab Partner: Labcorp

The Purpose of a Comprehensive Male Sexual Health Blood Test

Your sexual health is a major component of your overall wellness. That’s why it’s important to use a men’s sexual health test for regular monitoring, for your sake as well as any of your partners. With just one order, you get testing that assesses more than 30 different markers to give you a thorough picture of your health in everything from sexually transmitted infections to high cholesterol.

What the Comprehensive Male Sexual Health Panel Includes

| Marker | What It Measures | Clinical Relevance |
|—|—|—|
| Testosterone Free & Total | Bioavailable + total hormone | Primary driver of libido, erections, muscle, energy |
| Estradiol (Sensitive) | Estrogen level | High estradiol kills libido and causes ED |
| SHBG | Sex hormone binding globulin | High SHBG reduces free testosterone |
| LH | Luteinizing hormone | Distinguishes primary vs secondary hypogonadism |
| FSH | Follicle-stimulating hormone | Sperm production and testicular function |
| DHEA-S | Adrenal androgen | Fatigue, low drive, adrenal function |
| PSA | Prostate screening | Safety marker for testosterone therapy |
| CBC | Blood cell health, hematocrit | TRT safety — hematocrit must stay below 54% |
| CMP | Kidney, liver, glucose | Metabolic baseline and organ function |
| Lipid Panel | Cardiovascular risk | TRT affects cholesterol — baseline required |
| Thyroid (TSH) | Thyroid function | Low thyroid mimics low testosterone symptoms |
| Prolactin | Pituitary hormone | Elevated prolactin suppresses testosterone |
| Cortisol AM | Adrenal stress response | Chronic high cortisol crushes testosterone |

Why This Panel Is the Complete Male Sexual Health Evaluation

Erectile dysfunction, low libido, and poor sexual performance rarely have a single cause. The most common mistake men make is testing testosterone alone and stopping there — missing the other seven to ten hormonal, metabolic, and vascular factors that directly affect sexual health.

This comprehensive panel evaluates every major hormonal driver of male sexual function:

Testosterone is the obvious starting point — but free testosterone matters more than total. A man can have normal total testosterone and low free testosterone if SHBG is elevated. This panel measures both.

Estradiol — elevated estrogen in men directly suppresses libido, causes erectile dysfunction, and reduces sperm quality. Testosterone converts to estradiol through aromatization. Men with belly fat aromatize more — making estradiol testing essential in any male sexual health evaluation.

Prolactin — a hormone produced by the pituitary gland. Chronically elevated prolactin is one of the most overlooked causes of low testosterone, erectile dysfunction, and infertility. A small pituitary tumor (prolactinoma) is the most common cause of pathologically high prolactin.

Cortisol — the stress hormone. Chronically elevated cortisol from work stress, sleep deprivation, or underlying adrenal dysfunction directly suppresses gonadotropin release from the pituitary — lowering testosterone at the source.

Thyroid — hypothyroidism causes fatigue, low libido, and erectile dysfunction that is frequently misattributed to low testosterone. Treating the thyroid often resolves sexual symptoms without hormone therapy.

LH and FSH — distinguish whether low testosterone originates in the testes (high LH = primary hypogonadism) or the pituitary (low LH = secondary hypogonadism). This distinction determines the treatment pathway.

Reviewed by Edward Salko, D.O., Medical Director, Personalabs

What Does the Male Sexual Health Test Measure?

This men’s sexual wellness blood test and urinalysis panel includes the following items, depending on the lab you select for your testing:

Who Should Take a Men’s Test?

Men can and should take a male sexual health medical test if they need help diagnosing:

• Sexual infections or diseases such as syphilis, herpes, gonorrhea, and chlamydia
• Diabetes
• Hepatitis
• Thyroid or other hormonal disorders
• Testosterone deficiency
• Prostate cancer
• HIV
• Elevated cholesterol

Comprehensive Male Sexual Health Blood Test Preparation

You need to fast for 12 hours prior to taking a sexual test for males. Additionally, it’s important to avoid alcohol for a 24-hour period prior to giving your samples.

Men’s Sexual Health Test Results

You should have a physician review the male sexual health test results with you to better understand what they mean and get recommendations if treatment is necessary.

If you test positive for chlamydia, herpes 2, and/or gonorrhea, we will provide you with free STD counseling and a prescription referral to a pharmacy of your choice to get STD treatment. (Please note that you will have to pay for the medication at the pharmacy.) This service is meant to be the starting point for your treatment plan.

We only offer treatment prescriptions in the following states:

Arizona, California, Colorado, Connecticut, Delaware, Florida, Illinois, Indiana, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Missouri, Montana, Nebraska, Nevada, New Hampshire, North Carolina, Ohio, Oregon, Pennsylvania, South Carolina, Tennessee, Vermont, Virginia, Washington, Washington DC, West Virginia, Wisconsin, and Wyoming.

Where Can I Get a Sexual Test for Males Near Me?

At Personalabs, we’ve simplified the testing process so you can take charge of your health:

Step 1: Shop our selection of men’s health tests online. (Pre-approval from your doctor isn’t needed, depending on the state you live in.) Once you’ve purchased your test, download the lab order.

Step 2: Use our lab locator tool to find the Quest Diagnostics or Labcorp facility nearest you for testing.

Step 3: Bring the test order to the lab and get tested.

Step 4: Check for the results in your confidential and secure Personalabs account, typically within 2 to 10 business days. (Please contact us for an exact turnaround time, and we will work with the lab to meet your request.)

Explore our test collections today.

How Much Does a Male Sexual Health Panel Cost? Personalabs vs. Other Options

| Option | Typical Cost | Notes |
|—|—|—|
| Personalabs Comprehensive Panel | $655 | All 13 markers — physician order included |
| Urologist evaluation + labs | $500–$1,500+ | Office visit + partial panel + follow-up |
| Men’s health clinic (Low T center) | $200–$500/month | Ongoing membership — limited testing |
| Endocrinologist + labs | $600–$1,200+ | Specialist visit + incomplete panel |
| Ordering tests individually | $800–$1,200+ | Same tests ordered separately cost more |

Frequently Asked Questions: Comprehensive Male Sexual Health Panel