Creatinine is measured in a 24 hour urine sample to evaluate kidney function and calculate the glomerular filteration rate. It might be reduced in kidney failure and increased post exercise and fever.
Renal function test when used as part of creatinine clearance; crude marker for completeness of 24-hour urine collections when collected for other purposes.
Complete urine collections require vigilance on the part of nursing personnel. Ingestion of meat may increase creatinine values of urine collections as well as serum creatinine values. Drugs interfering with tubular creatinine secretion include cimetidine, trimethoprim, and probenecid.
Creatinine reabsorption occurs with very low urine flow rates. Entities in which reabsorption occurs include severe congestive heart failure, uncontrolled diabetes mellitus, and acute renal failure.
Assessing renal function in chronic kidney diseases.
Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning).
Creatinine, 24-Hour Urine
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